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81377  München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Hochschulprofessor. Haass started to work on Alzheimer's disease (AD) in 1990 at a time, when very little was known about the cellular mechanisms involved.  Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß.  Christian Haass hypothesized against the widely accepted general opinion rein this field that Aß may be produced from its precursor rein a physiologically weit verbreitet pathway and not necessarily rein a pathological process.  Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions.  This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved hinein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production rein patients.

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Together with an inter­dizipli­nary team he uncov­ered the molec­u­lar mecha­nisms of Alzheimer's disease and identi­fied target molecules for thera­peu­tic treatment.

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Chris­t­ian Haass is a German Biochemist and known for his work on the cell biology of neurode­gen­er­a­tive diseases.

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